Victoria Brown-Kennerly, PhD

Brown-Kennerly

Assistant Professor - Webster University
Department of Biological Sciences
470 E. Lockwood Ave, WEBH 13
St. Louis, MO  63119
(314) 246-8645
vbrownkennerly64@webster.edu

 

 

EDUCATION

2004 – 2006 Postdoctoral Scholar Washington University, St. Louis, MO
2001 – 2004 Postdoctoral Damon Runyon Fellow University of Washington, Seattle, WA
2001 PhD, Genetics and Molecular Biology, Emory University, Atlanta, GA
1993 BS, Biology (with distinction), University of Michigan, Ann Arbor, MI            

Assistant Professor, Department of Biological Sciences at Webster University, St. Louis, MO (2013 – present)

Research Assistant Professor and Director of Science & Technology Development, the Genome Technology Access Center at Washington University (2012 – 2013).  Managed team developing new assays and bioinformatics for high throughput genotyping and gene-expression typing platforms: next-generation amplicon-sequencing, and high throughput RT-qPCR, to support clinical trials: NCT01760005, NCT01757327,and NCT01779050.

Senior Scientist, Sigma-Aldrich / SAGE Labs, St. Louis, MO (2010).  Biochemically validated the MDR1a null and p53 null mutant rats, conducted intellectual property research for SAGE knockout rat models for human diseases, developed approach to p450 gene editing to humanize rats.

Instructor, Washington University Ctr. for Genome Sciences (2006 – 2010). Investigated fungal sugar sensing with regard to evolutionary genetics of GAL4, and studied colonization of the mammalian GI tract with Candida albicans (a ubiquitous human pathogen), using mice as model hosts.

Postdoctoral Scholar, Washington University Dept. of Genetics (2004 – 2006).  Advisor, Dr. H. Mark Johnston: Identified sugar sensor and signal transduction pathway in C. albicans, characterized genes controlled by the sensor, and established the pathway as critical for virulence during Candidemia (blood infection) in mice as model host.

Postdoctoral Fellow, University of Washington Dept. of Genome Sciences (2001 – 2004).

Advisor, Dr. Stanley Fields: Developed structure-function analysis of human Toll-like receptors, identified potential novel protein interactors for each receptor, and defined critical residues for binding to proximal signaling protein MyD88, using S. cerevisiae as a model eukaryotic cell.

Graduate Research Asst., Emory University Dept. of Biochemistry HHMI (1995 – 2001).

Advisor, Dr. Stephen T. Warren: Dissertation: RNA Binding by the Fragile X Mental Retardation Protein.  Developed novel RIP-CHIP technology (patented): mRNP immunoprecipitation coupled to microarray analysis to define the mRNAs regulated at translational level via FMRP.

Undergraduate Work-Study and Laboratory Technician I, Univ. of Michigan Dept. of Human Genetics (1992 – 1994).

Advisor, Dr. Jeffrey S. Chamberlain: Cloned the cDNA encoding the shortest protein isoform of the Duchenne Muscular Dystrophy gene (DMD Dp71), in pursuit of a 'mini-gene' suitable for theoretical adenoviral vector-based gene therapy.

 

PATENTS

20110136187 - Weinstein E, Brown-Kennerly V, Cui X; Genome Editing of Cytochrome P450 in Animals (2012)

20050130151 - Warren ST, Brown-Kennerly V, Jin P, Ceman S, Darnell RB, Darnell JC, Keene J, Tenenbaum SA; Method and identification of mRNA ligands to FMRP and their role in fragile X syndrome and associated disorders(2005)

 

FUNDING

Provost Student-Faculty Collaborative Research Grant, Webster University

  • Debaryomyces hansenii yeast: survival and effects on growth of common bacteria, with Raina Muthukumaru (2015)
  • Pogonomyrmex harvester ants: tunneling responses to common soil and water contaminants, with Robert Polzin (2015)

Faculty Research Grant, Assessment of Bacterial Diversity in a Changing Freshwater Community on Campus, Webster University, co-PI Dr. Mary Lai Preuss (2014 – 2015)

K01 Career Development Award, National Institute of Diabetes and Digestive and Kidney Diseases, Gut colonization by C. albicans: interactions with the host and its microbiota (2007 – 2012 awarded)

Scholarship, Marine Biological Laboratory Topics Course, Molecular Mycology - Current Approaches to Fungal Pathogenesis, Woods Hole, MA (2005)

Damon-Runyon Postdoctoral Fellowship, Characterization of Human TOLL-like Receptors (2002 – 2005)

NIH Postdoctoral Fellowship, National Institute of Allergy and Infectious Disease, declined as required (2002 – 2005)

Predoctoral Traineeship, Emory University Department of Genetics training grant, National Institute of General Medical Sciences (1996 – 1997)

 

AWARDS

American Society for Microbiology, Eukaryotic Cell Outstanding Young Investigator Award (2008)

AAAS/Science, Program for Excellence in Science nominee (2005)

American Society of Human Genetics, Pre-doctoral Research Award finalist (2000)

Emory University Graduate Division of Biological and Biomedical Sciences Excellence in Teaching Award (1998)

University of Michigan: James B. Angell Scholar, Regents Alumni Scholarship, Honors College (1989 – 1993)

 

PROFESSIONAL MEMBERSHIPS & WORKSHOPS

Member, the American Assoc. for the Advancement of Science (1997 – present)

Member, the Genetics Society of America (2006 – present)

Member, the American Society of Microbiology (2006 – present)

Peer-Reviewer, Euk Cell, Microbiol, Curr Biol, PLoS Genet, Infect Genet Evol, the Wellcome Trust(2004 – present)

Participant, Genomics in Education Project Workshop (HHMI) - Teaching bioinformatics via Drosophila genome annotation, Washington University (2015)

Participant, R-Basics Workshop, the Missouri Botanical Garden (2014)

Primary Science Writer, NIH working group, Washington University: "Infectious Diseases of the Urinary and Reproductive Tracts” unit, conference Moving into the Future: New Dimensions and Strategies for Women’s Health Research, Office of Research on Women’s Health (2009)

Coordinator, Candida albicans Microarray Project at Washington University (2006)

Participant, HHMI Future Faculty Fellows Workshop, Univ. of Washington (2003)

 

SERVICE

Webster Curriculum Committee (2014 – present)

Coordinator, Computational Biology curriculum, new undergraduate BS degree program FA2015, Webster University College of Arts & Sciences (2013 - Present)

Undergraduate Academic Advisor:fifteen BS/Biological Science & BA/Biology majors (2013 – present)

Thesis Committee, Nurse Anesthesia Masters of Science:

  • Vanessa Voudrie, BSN and Kim Molesky Powderly, BSN (2012): Mitotic Loss-of-Heterozygosity (LOH) in D. Melanogaster Following Isoflurane Administration
  • Rick Spangler, BSN and Timothy J. Dykstra, BSN (2012): Dose and Time-Dependent Effects of Isoflurane on beta-Amyloid Production in PC-12 Cells In Vitro

 

PUBLICATIONS

Carbery IC, Ji D, Harrington A, Brown V, Weinstein EJ, Liaw L, and X Cui, "Targeted Genome Modification in Mice Using Zinc Finger Nucleases" Genetics 2010186: 451-459

Sabina J and V Brown, "The Glucose Sensing Network in Candida albicans – A Sweet Spot for Hyphal Morphogenesis" Eukaryotic Cell 2009: 8: 1314-1320

Brown V,Sabina J, and M Johnston, "Specialized Sugar Sensing in Diverse Fungi" Current Biology 2009: 19: 436-41

Sexton JA, Brown V, and M Johnston, "Regulation of Sugar Transport and Metabolism by the Candida albicans Rgt1 Transcriptional Repressor" Yeast 2007: 24: 847-860.

Brown V, Sexton JA, and M Johnston, "A Glucose Sensor in Candida albicans" Eukaryotic Cell 2006: 5: 1726-1737

Brown V, Brown RA, Ozinsky A, Hesselberth JR, and S Fields, "Binding Specificity of the Toll-Like Receptor Cytoplasmic Domains" European Journal of Immunology 2006: 36: 742-753

Brown V, Jin P, Ceman S, Darnell JC, O’Donnell WT, Tenenbaum SA, Jin X, Feng Y, Wilkinson KD, Keene JD, Darnell RB, and ST Warren ST, "Microarray Identification of FMRP-Associated Brain mRNAs and Altered Translational Profile in Fragile X Syndrome" Cell 2001: 107: 477-487

Darnell JC, Jensen KB, Jin P, Brown V, Warren ST, and RB Darnell, "Fragile X Mental Retardation Protein mRNA Targets Harboring Intramolecular G-Quartets Encode Proteins Related to Synaptic Function" Cell 2001: 107: 488-498

Ceman S, Brown V, and ST Warren, "Isolation of a FMRP-Associated mRNP and the Identification of Nucleolin and the Fragile X - Related Proteins as Components of the Complex" Molecular and Cellular Biology 1999: 19: 7925-7932

Lumeng CN, Hauser M, Brown V, and JS Chamberlain, "Expression of the 71kDa dystrophin isoform (Dp71) evaluated by gene targeting" Brain Research 1999: 830: 174-178

Brown V, Small K, Lakkis L, Feng Y, Gunter C, Wilkinson KD, and ST Warren, "Purified Recombinant Fmrp Exhibits Selective RNA Binding as an Intrinsic Property of the Fragile X Mental Retardation Protein" The Journal of Biological Chemistry 1998: 73:15521-15527

Feng Y, Absher D, Eberhart DE, Brown V, Malter HE, and Warren ST, "FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes this Association" Molecular Cell 1997: 1:109-118.

Brown V and ST Warren, "Trinucleotide Repeats – Dynamic DNA and Human Disease" The Encyclopedia of Genetics (S. Brenner and J. H. Miller, eds.) Academic Press, New York, New York, 2001

Vignali M and V Brown-Kennerly, "Protein-Protein Interactions – A Molecular Cloning Manual" (E. Golemis, ed.) The Quarterly Review of Biology (A. D. Carlson and J. D. Thompson, eds.) University of Chicago Press, Chicago, IL, 2002: 77: 317

 

PRESENTATIONS

McCrary A, Rosenthal P, Fairman A, Brown-Kennerly V, and Preuss M,  “Assessment of Bacterial Diversity in a Changing Freshwater Community” poster, the American Association for the Advancement of Science, 2014, Chicago, IL

McCoy A, Brown-Kennerly V, Ji D, Carbery I, Weinstein E, and Cui X,  “Creation of novel rat models for cancer research using zinc finger nuclease (ZFN) technology” poster, 10th Annual Congress of the French Society of Cell and Gene Therapy, 2011, Nantes, France

Brown V, Johnston M, "Galactose Sensing Candida albicans" poster, the American Society for Microbiology, 9th Candida and Candidiasis Meeting, 2008, Jersey City, NJ

Brown V, Sexton JA, Johnston M, "Glucose Sensing Through Hgt4 in Candida albicans" poster, the American Society for Microbiology, 8th Candida and Candidiasis Meeting, 2006, Denver CO

Brown V,Jin P, Ceman S, Jin C, Wilkinson KD, Warren ST, "Messenger RNAs Associated with the Fragile X Mental Retardation Protein in Mouse Brain" slideshow, the American Society of Human Genetics, 2000

Jin P, Feng Y, Brown V, Warren ST,  "Identification of Polyribosomes-Associated mRNAs Regulated by the Fragile X mental Retardation Protein (FMRP) Using Oligonucleotide Microarrays" poster, the American Society of Human Genetics Annual Meeting, 2000

Ceman S, Kenneson A, Nelson R, Jin C. Lakkis L, Brown V, Wilkinson KD, Warren ST,  "Development and Characterization of a Unique Set of anti-FMRP Antibodies Using a Novel Strategy" poster, the American Society of Human Genetics Annual Meeting, 2000

Brown V,Ceman S, Warren ST,  "Identification of the Candidate RNAs Regulated by the Fragile X Mental Retardation Protein, Fmrp" Keystone Symposium: The Genetic Basis of Brain Development and Dysfunction, 2000

Brown VL, Small K, Lakkis L, Warren ST,  "Purification and Characterization of the Fragile X Mental Retardation Protein" Gordon Research Conference: Molecular Human Genetics, 1997

Feng Y, Absher D, Eberhart DE, Brown V, Malter HE, and ST Warren, "FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes this Association" The American Society of Human Genetics annual meeting, 1997

Brown, VL, Small K. Lakkis L, Wilkinson KD, Warren ST, "Purification and Characterization of the Fragile X Mental Retardation Protein" The American Society of Human Genetics annual meeting, 1997

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